ABSTRACT
【Objective】 To retrospectively analyze the clinical effects of apheresis and concentrated platelets under different transfusion strategies, so as to explore more scientific transfusion strategies. 【Methods】 A total of 279 patients with thrombocytopenia, admitted to our hospital during January 2020 and October 2021, were collected.They was divided into group A(apheresis platelet transfusion alone), group B(concentrated platelet transfusion alone), and group C(both apheresis and concentrated platelet transfusion). Platelet count of three groups were measured 24 hours before and after transfusion and their CCI values were calculated and compared to understand the differences in transfusion efficiency and adverse reactions, as well as the efficacy among three groups with different blood groups. 【Results】 Patients, received solo apheresis platelets, demonstrated a lower incidence of transfusion refractoriness and adverse reactions, but also a lower treatment efficacy(14.63±13.48)(P<0.05). However, the treatment efficacy of patients, received solo concentrated apheresis, could reach 16.00±21.77, but presented a higher incidence of transfusion refractoriness and adverse reactions. Patients, received both apheresis and concentrated platelets, maintained a good treatment efficacy(16.21±16.33), with a low incidence of transfusion refractoriness and adverse reactions.At the same time, different blood types also affect the treatment efficacy of platelet transfusion. 【Conclusion】 The simultaneous transfusion of apheresis and concentrated platelets contributes to the effective treatment of patients and lower incidence of adverse reactions.
ABSTRACT
【Objective】 To retrospectively analyze the guiding significance and effect of thromboelogram (TEG) in the clinical use of cryoprecipitation. 【Methods】 A total of 289 patients with fibrinogen reduction, admitted to our hospital between January 2018 and December 2021, were collected. They was divided into control group (using coagulation examination and clinical feature as the transfusion criteria) and observation group (above parameters plus TEG). The TEG index in the observation group before and after transfusion and Fg, APTT, PT, and TT in 2 groups of patients before and after transfusion were monitored. The efficacy and prognosis of different blood products and cryoprecipitate were compared between 2 groups of patients.) 【Results】 The efficacy of choprecipitate transfusion was better in the observation group than the control[Fg index after transfusion (g / L) 1.92±0.92 vs 1.80±1.00, P<0.05]. And less blood products were used in observation group as compared with the control[ RBC(U) 1.93±2.69 vs 2.81±3.25 (P<0.05); FFP(mL) 667±378 vs 879±455(P<0.05)]. No differences were noticed by hospital stay between the two groups, but the prognosis in the observed group was significantly better than that in the control. 【Conclusion】 It’s scientific and reasonable to apply TEG to guide the clinical transfusion of cryoprecipitate, so as to save blood resources and improve the prognosis.
ABSTRACT
Objective To investigate the correlation between the levels of Hcy ,VitB12 and folic acid with Alzheimer′s Disease(AD) .Methods Fifty-four patients with AD in this hospital were extracted as the AD group by using cluster sampling method ,and contemporaneous 50 persons undergoing healthy physical exami-nation were selected as the control group .The levels of serum Hcy ,VitB12 and folic acid were detected in the two groups .Then the correlation among 3 indicators was analyzed .Results Compared with the control group , the level of serum Hcy in the AD group was significantly increased (P<0 .05) ,the VitB12 and folic acid levels in the AD group were significantly decreased compared with the control group (P<0 .05) .The serum Hcy lev-el was negatively correlated with VitB12 and folic acid levels (r= -0 .751 ,-0 .807 ,P<0 .05) .The area under the receiver operating characteristic curves (AUC) of Hcy ,VitB12 and folic acid and their combine detection in AD patients were 0 .897 ,0 .176 ,0 .204 and 0 .933 respectively .Conclusion Serum Hcy ,VitB12 and folic acid have clinical diagnosis value in AD ,and the 3-indicator combined detection can increase the diagnosis efficiency .
ABSTRACT
EEG feedback therapy has some value in mental disease treatment. This article designs an EEG feedback system with complete function and good performance based on virtual instruments technology, and brings out project of hardware and software to develop the system. Prototype of the system is made and has some effect of clinic application in mental disease?